Educational information only. Not medical advice. Talk to a qualified healthcare professional before using any compound. Disclaimer

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Argireline

Skin & Hair

Argireline

Also known as Acetyl Hexapeptide-8 (formerly Acetyl Hexapeptide-3)

Limited human evidenceCosmetic or supplement

Price range: €15 through €24

Discussed for: Expression lines (topical Botox).

FIG. 2 ยท Amino-acid sequence of Argireline (6 residues)
  1. E
  2. E
  3. M
  4. Q
  5. R
  6. R
  • Hydrophobic
  • Polar
  • Positive charge
  • Negative charge
  • Glycine / proline
Effect strengthHow hard it acts on the body2/10
Proof levelHow well that is shown in humans4/10
Risk levelHow much can go wrong1/10

Editorial 1 to 10 estimates from published research, not measured values. How to read these

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01 / Identity

What it is

Argireline is a synthetic hexapeptide. Main reported uses: expression lines (topical Botox). Current status: cosmetic ingredient.

Molecule type
Synthetic hexapeptide
How it is taken
Topical cream/serum
Other names
Acetyl Hexapeptide-8 (formerly Acetyl Hexapeptide-3)

Route only. This library does not publish doses or protocols.

02 / Mechanism

How it is thought to work

Slightly reduces nerve signals to small facial muscles

Mechanisms seen in cells or animals do not always happen the same way in people.

03 / Potential benefits

What people use it for

Expression lines (topical Botox)

Limited human evidence

Small or low-quality human data. Most of what is claimed comes from animals, cells or anecdotes.

Listed uses are what people use it for, not proven outcomes.

04 / Known risks

Side effects and risks

Mild skin irritation

Risk level 1 of 10

Lower risk score: reported side effects are mostly mild. Low risk is not no risk, especially for unregulated products.

Unknown long-term effects count as a risk, not as a clean record.

05 / Regulatory

Regulatory status

Status
Cosmetic or supplement
Details
Cosmetic ingredient
Sport (WADA)
Not listed

Status reflects information up to mid-2026 and changes over time. Check current sources.

06 / Evidence quality

How good is the evidence?

Limited: small cosmetic studies

How we grade evidence

07 / Notes and sources

Notes and sources

  • Talk to a pharmacist or doctor before combining supplements with medicines.
  • Source: Peptide Reference Table, an editorial review of published research up to mid-2026. Scores are 1 to 10 editorial estimates, not measured values. Regulatory and WADA status change over time.

Educational information only. Not medical advice. Talk to a qualified healthcare professional before using any compound.

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