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Spermidine

Non-peptide Adjuncts

Spermidine

Also known as Polyamine; found in wheat germ, natto

Limited human evidenceCosmetic or supplementNot a peptide

Price range: €15 through €26

Discussed for: Autophagy, longevity.

Sequence: not listed. Modified or non-standard residues are left out on purpose.

Effect strengthHow hard it acts on the body2/10
Proof levelHow well that is shown in humans3/10
Risk levelHow much can go wrong2/10

Editorial 1 to 10 estimates from published research, not measured values. How to read these

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01 / Identity

What it is

Spermidine is a small molecule (polyamine), not a peptide. Main reported uses: autophagy, longevity. Current status: supplement / food component.

Molecule type
Small molecule (polyamine), not a peptide
How it is taken
Oral
Other names
Polyamine; found in wheat germ, natto

Route only. This library does not publish doses or protocols.

02 / Mechanism

How it is thought to work

Polyamine that induces autophagy, the cell's recycling process

Mechanisms seen in cells or animals do not always happen the same way in people.

03 / Potential benefits

What people use it for

Autophagy, longevity

Limited human evidence

Small or low-quality human data. Most of what is claimed comes from animals, cells or anecdotes.

Listed uses are what people use it for, not proven outcomes.

04 / Known risks

Side effects and risks

Generally well tolerated; GI effects

Risk level 2 of 10

Lower risk score: reported side effects are mostly mild. Low risk is not no risk, especially for unregulated products.

Unknown long-term effects count as a risk, not as a clean record.

05 / Regulatory

Regulatory status

Status
Cosmetic or supplement
Details
Supplement / food component
Sport (WADA)
Not listed

Status reflects information up to mid-2026 and changes over time. Check current sources.

06 / Evidence quality

How good is the evidence?

Limited: small human trials, strong animal data

How we grade evidence

07 / Notes and sources

Notes and sources

  • Not technically a peptide. It is listed because it is often sold or discussed alongside peptides.
  • Talk to a pharmacist or doctor before combining supplements with medicines.
  • Source: Peptide Reference Table, an editorial review of published research up to mid-2026. Scores are 1 to 10 editorial estimates, not measured values. Regulatory and WADA status change over time.

Educational information only. Not medical advice. Talk to a qualified healthcare professional before using any compound.

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