Educational information only. Not medical advice. Talk to a qualified healthcare professional before using any compound. Disclaimer

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Dihexa

Cognitive & Brain

Dihexa

Also known as PNB-0408

Animal or no human dataNot approvedWADA prohibited

Price range: €75 through €150

Discussed for: Memory, cognition.

Sequence: not listed. Modified or non-standard residues are left out on purpose.

Effect strengthHow hard it acts on the body5/10
Proof levelHow well that is shown in humans1/10
Risk levelHow much can go wrong7/10

Editorial 1 to 10 estimates from published research, not measured values. How to read these

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01 / Identity

What it is

Dihexa is a small peptide-like molecule. Main reported uses: memory, cognition. Current status: not approved anywhere. FDA flagged it as a compounding safety risk (2023).

Molecule type
Small peptide-like molecule
How it is taken
Oral, topical, injection
Other names
PNB-0408

Route only. This library does not publish doses or protocols.

02 / Mechanism

How it is thought to work

Promotes new brain connections via HGF/c-Met pathway

Mechanisms seen in cells or animals do not always happen the same way in people.

03 / Potential benefits

What people use it for

Memory, cognition

Animal or no human data

No meaningful human data. Effects and safety in people are unknown, which is not the same as safe.

Listed uses are what people use it for, not proven outcomes.

04 / Known risks

Side effects and risks

Unknown; c-Met pathway linked to cancer growth (theoretical)

Risk level 7 of 10

High risk score: serious harms are documented or plausible, and there is little data to rule them out.

Unknown long-term effects count as a risk, not as a clean record.

05 / Regulatory

Regulatory status

Status
Not approved
Details
Not approved anywhere. FDA flagged it as a compounding safety risk (2023)
Sport (WADA)
Yes: S0 (unapproved substance)

Status reflects information up to mid-2026 and changes over time. Check current sources.

06 / Evidence quality

How good is the evidence?

Animal only

How we grade evidence

07 / Notes and sources

Notes and sources

  • In 2023 the FDA placed it on its list of bulk substances with significant safety concerns for compounding.
  • Animal only means effects and safety in humans are unknown, not that they are proven safe.
  • Products sold online as research peptides are unregulated. Tests of such products often find wrong amounts, impurities or a different compound.
  • Anyone using compounds like this regularly should have medical supervision and bloodwork (for example IGF-1, glucose and HbA1c, hormones, lipids).
  • Source: Peptide Reference Table, an editorial review of published research up to mid-2026. Scores are 1 to 10 editorial estimates, not measured values. Regulatory and WADA status change over time.

Educational information only. Not medical advice. Talk to a qualified healthcare professional before using any compound.

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