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Epitalon

Longevity & Anti-aging

Epitalon

Also known as Epithalon, Epithalone, AEDG peptide, Ala-Glu-Asp-Gly

Limited human evidenceNot approvedWADA prohibited

Price range: €25 through €40

Discussed for: Longevity, sleep, telomere support.

FIG. 2 ยท Amino-acid sequence of Epitalon (4 residues)
  1. A
  2. E
  3. D
  4. G
  • Hydrophobic
  • Polar
  • Positive charge
  • Negative charge
  • Glycine / proline
Effect strengthHow hard it acts on the body3/10
Proof levelHow well that is shown in humans2/10
Risk levelHow much can go wrong3/10

Editorial 1 to 10 estimates from published research, not measured values. How to read these

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01 / Identity

What it is

Epitalon is a synthetic tetrapeptide (4 amino acids). Main reported uses: longevity, sleep, telomere support. Current status: not approved anywhere. FDA flagged it as a compounding safety risk (2023).

Molecule type
Synthetic tetrapeptide (4 amino acids)
How it is taken
Injection (SC), nasal
Other names
Epithalon, Epithalone, AEDG peptide, Ala-Glu-Asp-Gly

Route only. This library does not publish doses or protocols.

02 / Mechanism

How it is thought to work

Acts on the pineal gland, raises melatonin; lab studies show telomerase activation

Mechanisms seen in cells or animals do not always happen the same way in people.

03 / Potential benefits

What people use it for

Longevity, sleep, telomere support

Limited human evidence

Small or low-quality human data. Most of what is claimed comes from animals, cells or anecdotes.

Listed uses are what people use it for, not proven outcomes.

04 / Known risks

Side effects and risks

Injection-site reactions; long-term effects unknown

Risk level 3 of 10

Lower risk score: reported side effects are mostly mild. Low risk is not no risk, especially for unregulated products.

Unknown long-term effects count as a risk, not as a clean record.

05 / Regulatory

Regulatory status

Status
Not approved
Details
Not approved anywhere. FDA flagged it as a compounding safety risk (2023)
Sport (WADA)
Yes: S0 (unapproved substance)

Status reflects information up to mid-2026 and changes over time. Check current sources.

06 / Evidence quality

How good is the evidence?

Limited: small Russian studies, mostly animal

How we grade evidence

07 / Notes and sources

Notes and sources

  • In 2023 the FDA placed it on its list of bulk substances with significant safety concerns for compounding.
  • Products sold online as research peptides are unregulated. Tests of such products often find wrong amounts, impurities or a different compound.
  • Anyone using compounds like this regularly should have medical supervision and bloodwork (for example IGF-1, glucose and HbA1c, hormones, lipids).
  • Source: Peptide Reference Table, an editorial review of published research up to mid-2026. Scores are 1 to 10 editorial estimates, not measured values. Regulatory and WADA status change over time.

Educational information only. Not medical advice. Talk to a qualified healthcare professional before using any compound.

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