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Kisspeptin-10

Hormones & Testosterone

Kisspeptin-10

Also known as Metastin 45-54, KP-10

Moderate human evidenceNot approvedWADA prohibited

Price range: €39 through €67

Discussed for: Boost natural testosterone, libido.

FIG. 2 ยท Amino-acid sequence of Kisspeptin-10 (10 residues)
  1. Y
  2. N
  3. W
  4. N
  5. S
  6. F
  7. G
  8. L
  9. R
  10. F
  • Hydrophobic
  • Polar
  • Positive charge
  • Negative charge
  • Glycine / proline
Effect strengthHow hard it acts on the body6/10
Proof levelHow well that is shown in humans5/10
Risk levelHow much can go wrong3/10

Editorial 1 to 10 estimates from published research, not measured values. How to read these

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01 / Identity

What it is

Kisspeptin-10 is a natural peptide fragment (10 aa). Main reported uses: boost natural testosterone, libido. Current status: not approved anywhere. FDA flagged it as a compounding safety risk (2023).

Molecule type
Natural peptide fragment (10 aa)
How it is taken
Injection (SC)
Other names
Metastin 45-54, KP-10

Route only. This library does not publish doses or protocols.

02 / Mechanism

How it is thought to work

Triggers GnRH, then LH and FSH, then the testes make testosterone

03 / Potential benefits

What people use it for

Boost natural testosterone, libido

Moderate human evidence

Some human trials exist, but they are smaller, shorter or mixed.

Listed uses are what people use it for, not proven outcomes.

04 / Known risks

Side effects and risks

Short-lived effect, possible desensitization

Risk level 3 of 10

Lower risk score: reported side effects are mostly mild. Low risk is not no risk, especially for unregulated products.

Unknown long-term effects count as a risk, not as a clean record.

05 / Regulatory

Regulatory status

Status
Not approved
Details
Not approved anywhere. FDA flagged it as a compounding safety risk (2023)
Sport (WADA)
Yes: S2 (peptide hormones / GH factors)

Status reflects information up to mid-2026 and changes over time. Check current sources.

06 / Evidence quality

How good is the evidence?

Moderate: small human studies

How we grade evidence

07 / Notes and sources

Notes and sources

  • In 2023 the FDA placed it on its list of bulk substances with significant safety concerns for compounding.
  • Products sold online as research peptides are unregulated. Tests of such products often find wrong amounts, impurities or a different compound.
  • Anyone using compounds like this regularly should have medical supervision and bloodwork (for example IGF-1, glucose and HbA1c, hormones, lipids).
  • Source: Peptide Reference Table, an editorial review of published research up to mid-2026. Scores are 1 to 10 editorial estimates, not measured values. Regulatory and WADA status change over time.

Educational information only. Not medical advice. Talk to a qualified healthcare professional before using any compound.

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