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Matrixyl

Skin & Hair

Matrixyl

Also known as Palmitoyl Pentapeptide-4, Pal-KTTKS; Matrixyl 3000 variant

Limited human evidenceCosmetic or supplement

Price range: €21 through €35

Discussed for: Wrinkle reduction.

FIG. 2 ยท Amino-acid sequence of Matrixyl (5 residues)
  1. K
  2. T
  3. T
  4. K
  5. S
  • Hydrophobic
  • Polar
  • Positive charge
  • Negative charge
  • Glycine / proline
Effect strengthHow hard it acts on the body3/10
Proof levelHow well that is shown in humans4/10
Risk levelHow much can go wrong1/10

Editorial 1 to 10 estimates from published research, not measured values. How to read these

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01 / Identity

What it is

Matrixyl is a synthetic lipopeptide. Main reported uses: wrinkle reduction. Current status: cosmetic ingredient.

Molecule type
Synthetic lipopeptide
How it is taken
Topical cream/serum
Other names
Palmitoyl Pentapeptide-4, Pal-KTTKS; Matrixyl 3000 variant

Route only. This library does not publish doses or protocols.

02 / Mechanism

How it is thought to work

Signals skin to make more collagen

Mechanisms seen in cells or animals do not always happen the same way in people.

03 / Potential benefits

What people use it for

Wrinkle reduction

Limited human evidence

Small or low-quality human data. Most of what is claimed comes from animals, cells or anecdotes.

Listed uses are what people use it for, not proven outcomes.

04 / Known risks

Side effects and risks

Mild skin irritation

Risk level 1 of 10

Lower risk score: reported side effects are mostly mild. Low risk is not no risk, especially for unregulated products.

Unknown long-term effects count as a risk, not as a clean record.

05 / Regulatory

Regulatory status

Status
Cosmetic or supplement
Details
Cosmetic ingredient
Sport (WADA)
Not listed

Status reflects information up to mid-2026 and changes over time. Check current sources.

06 / Evidence quality

How good is the evidence?

Limited: small cosmetic studies

How we grade evidence

07 / Notes and sources

Notes and sources

  • Talk to a pharmacist or doctor before combining supplements with medicines.
  • Source: Peptide Reference Table, an editorial review of published research up to mid-2026. Scores are 1 to 10 editorial estimates, not measured values. Regulatory and WADA status change over time.

Educational information only. Not medical advice. Talk to a qualified healthcare professional before using any compound.

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