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Sermorelin

Growth Hormone & Muscle

Sermorelin

Also known as GRF 1-29, Geref (former brand)

Moderate human evidencePrescription in some countriesWADA prohibited

Price range: €48 through €92

Discussed for: Natural-style GH boost for anti-aging.

FIG. 2 ยท Amino-acid sequence of Sermorelin (29 residues)
  1. Y
  2. A
  3. D
  4. A
  5. I
  6. F
  7. T
  8. N
  9. S
  10. Y
  11. R
  12. K
  13. V
  14. L
  15. G
  16. Q
  17. L
  18. S
  19. A
  20. R
  21. K
  22. L
  23. L
  24. Q
  25. D
  26. I
  27. M
  28. S
  29. R
  • Hydrophobic
  • Polar
  • Positive charge
  • Negative charge
  • Glycine / proline
Effect strengthHow hard it acts on the body4/10
Proof levelHow well that is shown in humans6/10
Risk levelHow much can go wrong3/10

Editorial 1 to 10 estimates from published research, not measured values. How to read these

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01 / Identity

What it is

Sermorelin is a synthetic GHRH fragment (29 aa). Main reported uses: natural-style GH boost for anti-aging. Current status: was FDA-approved (withdrawn commercially 2008); available via compounding.

Molecule type
Synthetic GHRH fragment (29 aa)
How it is taken
Injection (SC)
Other names
GRF 1-29, Geref (former brand)

Route only. This library does not publish doses or protocols.

02 / Mechanism

How it is thought to work

GHRH analog that stimulates the pituitary's own GH release

03 / Potential benefits

What people use it for

Natural-style GH boost for anti-aging

Moderate human evidence

Some human trials exist, but they are smaller, shorter or mixed.

Listed uses are what people use it for, not proven outcomes.

04 / Known risks

Side effects and risks

Injection-site pain, flushing, headache

Risk level 3 of 10

Lower risk score: reported side effects are mostly mild. Low risk is not no risk, especially for unregulated products.

Unknown long-term effects count as a risk, not as a clean record.

05 / Regulatory

Regulatory status

Status
Prescription in some countries
Details
Was FDA-approved (withdrawn commercially 2008); available via compounding
Sport (WADA)
Yes: S2 (peptide hormones / GH factors)

Status reflects information up to mid-2026 and changes over time. Check current sources.

06 / Evidence quality

How good is the evidence?

Moderate: older human studies

How we grade evidence

07 / Notes and sources

Notes and sources

  • Growth-factor peptides carry a theoretical risk of feeding existing cancers.
  • Anyone using compounds like this regularly should have medical supervision and bloodwork (for example IGF-1, glucose and HbA1c, hormones, lipids).
  • Source: Peptide Reference Table, an editorial review of published research up to mid-2026. Scores are 1 to 10 editorial estimates, not measured values. Regulatory and WADA status change over time.

Educational information only. Not medical advice. Talk to a qualified healthcare professional before using any compound.

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