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MOTS-c

Longevity & Anti-aging

MOTS-c

Also known as Mitochondrial ORF of the 12S rRNA type-c, MOTSc, Mots

Animal or no human dataNot approvedWADA prohibited

Price range: €25 through €49

Discussed for: Metabolism, endurance, insulin sensitivity.

FIG. 2 ยท Amino-acid sequence of MOTS-c (16 residues)
  1. M
  2. R
  3. W
  4. Q
  5. E
  6. M
  7. G
  8. Y
  9. I
  10. F
  11. Y
  12. P
  13. R
  14. K
  15. L
  16. R
  • Hydrophobic
  • Polar
  • Positive charge
  • Negative charge
  • Glycine / proline
Effect strengthHow hard it acts on the body3/10
Proof levelHow well that is shown in humans1/10
Risk levelHow much can go wrong3/10

Editorial 1 to 10 estimates from published research, not measured values. How to read these

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01 / Identity

What it is

MOTS-c is a natural mitochondrial peptide (16 aa). Main reported uses: metabolism, endurance, insulin sensitivity. Current status: not approved anywhere. FDA flagged it as a compounding safety risk (2023).

Molecule type
Natural mitochondrial peptide (16 aa)
How it is taken
Injection (SC)
Other names
Mitochondrial ORF of the 12S rRNA type-c, MOTSc, Mots

Route only. This library does not publish doses or protocols.

02 / Mechanism

How it is thought to work

Mitochondria-derived peptide that activates AMPK, improving glucose use and energy

Mechanisms seen in cells or animals do not always happen the same way in people.

03 / Potential benefits

What people use it for

Metabolism, endurance, insulin sensitivity

Animal or no human data

No meaningful human data. Effects and safety in people are unknown, which is not the same as safe.

Listed uses are what people use it for, not proven outcomes.

04 / Known risks

Side effects and risks

Unknown in humans; fatigue and heart-rate changes reported anecdotally

Risk level 3 of 10

Lower risk score: reported side effects are mostly mild. Low risk is not no risk, especially for unregulated products.

Unknown long-term effects count as a risk, not as a clean record.

05 / Regulatory

Regulatory status

Status
Not approved
Details
Not approved anywhere. FDA flagged it as a compounding safety risk (2023)
Sport (WADA)
Yes: S0 (unapproved substance)

Status reflects information up to mid-2026 and changes over time. Check current sources.

06 / Evidence quality

How good is the evidence?

Animal only

How we grade evidence

07 / Notes and sources

Notes and sources

  • In 2023 the FDA placed it on its list of bulk substances with significant safety concerns for compounding.
  • Animal only means effects and safety in humans are unknown, not that they are proven safe.
  • Products sold online as research peptides are unregulated. Tests of such products often find wrong amounts, impurities or a different compound.
  • Anyone using compounds like this regularly should have medical supervision and bloodwork (for example IGF-1, glucose and HbA1c, hormones, lipids).
  • Source: Peptide Reference Table, an editorial review of published research up to mid-2026. Scores are 1 to 10 editorial estimates, not measured values. Regulatory and WADA status change over time.

Educational information only. Not medical advice. Talk to a qualified healthcare professional before using any compound.

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